1,869 posts. In addition, another research study. Medications that are designed to thin the blood or slow blood clotting may also be unsafe to pair with Lions Mane. Learn more about how mushrooms can benefit a persons health. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Research has found that lions mane may protect against dementia, reduce mild symptoms of anxiety and depression, and help repair nerve damage. These statements have not been evaluated by the Food and Drug Administration. Animal studies suggest that lions mane mushroom and its extracts are very safe, even at high doses. Further more, during the entire 56 days neither testosterone nor libido was negatively effected. 2015;25(24):5712-5. In addition, the best dosage of Lion's mane varies from one person to the other as different people react differently to this functional fungus. January 03, 2023 Antihyperglycemic and antihyperlipidemic activities of aqueous extract of, Liu, J. H., Li, L., Shang, X. D., Zhang, J. L., & Tan, Q. Lion's mane can prevent metastasis of cancer cells, eliminating the pain associated with cancer cells jumping from one location to the other. Is the ketogenic diet right for autoimmune conditions? Some research suggests that extracts of lions mane mushrooms may encourage nerve cells to grow and repair more quickly. It has also been studied a bit for improving sleep, which can help with Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. However, the capsule dosage can vary depending on the brand and the concentration of the powder inside. Likewise, taking lion's mane along with anticoagulant/antiplatelet drugs can cause blood clotting difficulties that can result in bleeding or bruising. Dietary supplementation of lion's mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), and spatial memory in wild-type mice. (59). Those risks are usually higher for those who take prescription or over-the-counter medications since there is some possibility of Lions Mane drug interactions. Int J Med Mushrooms. The ability of lions mane mushroom to promote nerve growth and protect the brain from Alzheimers-related damage may explain some of its beneficial effects on brain health. View abstract. However, start lower at 1,000 mg daily and work your way up to avoid side effects. 2014 Aug 26. I am doing a job and studying a post-graduate course which requires a lot of studying. I would be very grateful if someone can help me in this regard. Lee JS, Min KM, Cho JY, Hong EK. In a small Japanese study, women with a variety of health complaints, including menopausal symptoms and poor sleep quality, ate cookies containing lions mane extracts or placebo cookies for 4 weeks. Several animal studies have found that lions mane extract reduced markers of inflammation and oxidative stress in rodents and may be especially useful in managing inflammatory bowel disease, liver damage, and stroke (22, 50, 51). The researchers suggest that this is due to the extracts anti-inflammatory effects. There were also no withdrawal symptoms, other than mild symptoms of depression returning when taken off lions mane supplement. If you experience discomfort or side effects, reduce your dosage. BMC Complement Altern Med. Its also been shown to have strong anti-inflammatory, antioxidant, and immune-boosting abilities and to lower the risk of heart disease, cancer, ulcers, and diabetes in animals. Because it has antidepressant features, Lions Mane may improve mood and motivation. In many causes, you may still be able to safely pair Lions Mane with other medications with the help of your doctor. Yi, Z., Shao-long, Y., Ai-hong, W., Zhi-chun, S., Ya-fen, Z., Ye-ting, X., & Yu-ling, H. (2015, April 16). Last medically reviewed on February 6, 2023. Wang M, Gao Y, Xu D, Gao Q. Mushrooms are hearty and versatile, making them an excellent substitute when a recipe calls for meat. When combined with antidiabetes medications designed to lower blood sugar, it could cause the blood sugar levels to drop too low, which could be cause for concern. Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment [Abstract]. Hericium erinaceus (Bull. Therefore, a lower dosage may help you enjoy the benefits you are looking for, whether it's to fight depression and anxiety, improve cognitive function, or fight inflammation. View abstract. View abstract. Biomed Res. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. The most common cause for adverse reaction, however, is an adverse drug interaction. I have severe brain fog. However, no studies have been conducted involving humans to determine if lions mane would have the same therapeutic effect on nervous system injuries as animal research has suggested. Additionally, animal studies have found that lions mane may help protect against Alzheimers disease, a degenerative brain disease that causes progressive memory loss. View abstract. Lion's mane mushroom might lower blood sugar levels. A healthcare professional can provide personalized advice on the best time to take Lion's Mane mushroom based on your specific needs and circumstances. Bioorg Med Chem Lett. Possible health benefits include lowering cancer risk and boosting the immune system. Int J Med Mushrooms. Lion's mane mushroom might slow blood clotting. If you are incorporating Lion's mane powder into your diet to reduce the symptoms of depression and anxiety, a dosage of up to 2g/day (2,000 mg per day) is effective. lions mane mushroom Evid Based Complement Alternat Med. It might also protect nerves from becoming damaged. View abstract. I might be wrong though, I know that it's main action is Int J Med Mushrooms. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. Lions mane mushrooms are available over the counter in some of the following forms: However, researchers advise that there are currently no guidelines to ensure these products are safe and effective. These two conditions are characterized by memory loss. You may want to talk with a doctor about the right dosage for you. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus (Bull.:Fr.) However, I am not dettered from using bacopa because it seemed to have normalized completely by day 56 (Signh A & Signh SK, 2009). Chronically high blood sugar levels eventually cause complications like kidney disease, nerve damage in the hands and feet, and vision loss. One study involving menopausal women experiencing irritability and low concentration found that supplementing with lions mane showed improvements in feelings of depression and anxiety. In fact, the mushroom was not found to produce any adverse effects in rodents, even when used in high doses. Therefore, we recommend a dosage of up to 2,000 mg daily, starting with 1,000 mg, for safety purposes. Consult your health care provider before taking if you are pregnant or nursing, or have any other medical conditions. Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation, (6)https://www.frontiersin.org/articles/10.3389/fphar.2019.01174/full. What are chaga mushrooms? How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/pubmed/22135902, https://www.hindawi.com/journals/ecam/2012/464238/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237458/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855563/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714447/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492111/, https://www.ncbi.nlm.nih.gov/pubmed/21779573, https://www.ncbi.nlm.nih.gov/pubmed/27816657, https://www.ncbi.nlm.nih.gov/pubmed/24631140, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852124/#__ffn_sectitle, https://www.ncbi.nlm.nih.gov/pubmed/26364939, https://www.ncbi.nlm.nih.gov/pubmed/18844328, https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en, https://www.ncbi.nlm.nih.gov/pubmed/26853959, https://www.ncbi.nlm.nih.gov/pubmed/28266682, https://www.ncbi.nlm.nih.gov/pubmed/26853960, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176599/, https://www.ncbi.nlm.nih.gov/pubmed/26150007, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415746/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133811/. View abstract. Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. Lee KF, Chen JH, Teng CC, et al. : Fr.) However, for Lion's mane mushroom supplements, a dosage between 250 and 4,000 mg daily seems to produce great results for different people. B., Guo, Z., Xie, F., & Zhai, A. Lion's mane powder can be compressed into a capsule for convenient and easy consumption. When using Lion's mane extracts, 250 mg to 750 mg per day should be adequatefor fighting diabetes, maintaining healthy blood sugar levels, reducing cancer risk, etc. Here are nine health benefits of lions mane mushrooms and their extracts, along with dosages, preparation, and side effects. 2018;20(5):485-494. Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. Biol Pharm Bull. 2016;16(1):170. Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Take lions mane capsules according to the manufacturers instructions. Yang BK, Park JB, Song CH. Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology [Abstract]. Doctoral Degree. (7), Taking three 400-mg capsules daily for 8 weeks helped relieve depression, anxiety, and sleep disorders for 77 people who were overweight or had obesity, according to a 2019 study. Hericium erinaceus, also known as Lion's mane mushroom, has been shown to have various health benefits, including antioxidative, antidiabetic, anticancer, anti-inflammatory, antimicrobial, antihyperglycemic, and hypolipidemic effects. Li G, Yu K, Li F, et al. BMC Complement Altern Med. Lions Mane research is currently limited, but you can find both human and animal trials in which the supplement is generally well tolerated. Lion's Mane tinctures are a convenient and potent way to consume this mushroom. Mycelium vs Fruiting Body: Which Mushroom Supplements are the Best? Cui F, Gao X, Zhang J, et al. A double-blind study of effectiveness of hericium erinaceus pers therapy on chronic atrophic gastritis. These effects may partly be due to beneficial changes in gut bacteria that stimulate the immune system (54). Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells. A., Sabaratnam, V., Wong, K. H., Kuppusamy, U. R., Abdullah, N., & Ismail, S. (2011). Most studies on lions mane mushrooms have used animals, but it appears to be safe to eat the mushrooms in moderate quantities, as people do in many countries in Asia. If you use a powdered form of the fungi, it is best to first begin with a small dose to see how it affects you. Below, we will help you avoid taking too much Lion's mane when using any of these options. 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